Zoloft (sertraline) is used to treat depression, panic attacks, obsessive compulsive disorders (OCD), and post-traumatic stress disorder (PTSD). Zoloft works by helping to restore the balance of certain natural chemicals in the brain. Zoloft has also been used to treat a severe form of premenstrual syndrome (premenstrual dysphoric disorder- PMDD) and a sexual function problem in men (premature ejaculation).

The following information is a summary. It is not intended to replace a doctor's instructions.

About Zoloft

Uses of Zoloft

Zoloft is used to treat depression.

Zoloft Directions

Take Zoloft by mouth usually once daily with or without food; or as directed by your doctor. It is recommended that you take your dosage at the same time each day, either in the morning or in the evening. The dosage is based on your medical condition and response to therapy. It is important to continue taking Zoloft as prescribed even if you feel well. Also, do not stop taking this medication without consulting your doctor. It may take up to 4 weeks before the full benefit of Zoloft takes effect.

Zoloft Side Effects

Nausea, headache, diarrhea, trouble sleeping, dry mouth, drowsiness, dizziness, or upset stomach may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: loss of appetite, unusual weight loss, unusual or severe mental/mood changes, increased sweating/flushing, unusual fatigue, uncontrolled movements (tremor), decreased interest in sex. Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, changes in sexual ability, painful and/or prolonged erection. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular heartbeat, chest pain, muscle pain, trouble swallowing, ringing in in the ears, seizures. An allergic reaction to Zoloft is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Zoloft Precautions

Tell your doctor your medical history, especially of: liver problems, kidney disease, seizures, heart problems, any allergies. Zoloft may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Caution is advised when using Zoloft in the elderly because they may be more sensitive to the effects of the drug. Zoloft should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Zoloft passes into breast milk. Because of the potential risk to the infant, breast-feeding while using Zoloft is not recommended. Consult your doctor before breast-feeding.

Zoloft Drug Interactions

Certain medications taken with Zoloft could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before or after treatment with Zoloft. Consult your doctor or pharmacist for additional information. Zoloft is not recommended for use with: weight loss drugs (e.g., sibutramine, phentermine), terfenadine, astemizole. Ask your doctor or pharmacist for more details. Tell your doctor of all prescription and nonprescription medication you may use, especially: other SSRI antidepressants (e.g., citalopram, fluoxetine), nefazodone, venlafaxine, "triptan" migraine drugs (e.g., sumatriptan, zolmitriptan), tramadol, tricyclic antidepressants (e.g., amitriptyline, nortriptyline), cimetidine, flecainide, propafenone, clozapine, trazodone, lithium, tryptophan, "blood thinners" (e.g., warfarin), any herbal/natural products (e.g., melatonin, St John's wort, ayahuasca). Tell your doctor if you take any drugs that cause drowsiness such as: medicine for sleep, sedatives, tranquilizers, anti- anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, certain antihistamines (e.g., diphenhydramine). Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, sotalol, quinidine, procainamide, sparfloxacin, "water pills" (diuretics such as furosemide or hydrochlorothiazide). Ask your doctor or pharmacist for more details. Do not start or stop any medicine without doctor or pharmacist approval.

Missed Dose of Zoloft

Take any missed dose of Zoloft as soon as possible but not if it is within 4 hours of the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose of Zoloft.

Zoloft Overdose

If overdose of Zoloft is suspected, contact your local poison control center or emergency room immediately. Symptoms of Zoloft overdose may include seizures, hallucinations, rapid heart rate, and loss of consciousness.

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